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Publications | Seidel Group

  1. Making fluorescence-based integrative structures and associated kinetic information accessible.
    Hanke, C. A., Westbrook, J. D., Webb, B. M., Peulen, T.-O., Lawson, C. L., Sali, A., Berman, H. M., Seidel, C. A. M., Vallat, B.
    Nat. Methods (2024)
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  2. Glutamate helps unmask the differences in driving forces for phase separation versus 2 clustering of FET family proteins in sub-saturated solutions.
    Kar, M., Vogel, L. T., Chauhan, G., Ausserwöger, H., Welsh, T. J., Kamath, A. R., Knowles, T. P. J., Hyman, A. A., Seidel, C. A. M., Pappu, R. V.
    Nat. Commun. 15, final revisions (2024), bioRxiv, preprint (2023)
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  3. An optofluidic antenna for enhancing the sensitivity of single-emitter measurements.
    Morales-Inostroza, L., Folz, J., Kühnemuth, R., Felekyan, S. Wieser, F.-F., Seidel, C. A. M., Götzinger, S., Sandoghdar, V.
    Nat. Commun. 15, e2545 (2024)
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  4. IHMCIF: An Extension of the PDBx/mmCIF Data Standard for Integrative Structure Determination Methods.
    Vallat, B., Webb, B. M., Westbrook, J. D., Goddard, T. D., Hanke, C. A., Graziadei, A., Peisach, E., Zalevsky, A., Sagendorf, J., Tangmunarunkit, H., Voinea, S., Sekharan, M., Yu, J., Bonvin, A. A. M. J. J., DiMaio, F., Hummer, G., Meiler, J., Tajkhorshid, E., Ferrin, T. E., Lawson, C. L., Leitner, A., Rappsilber, J., Seidel, C. A. M., Jeffries, C. M., Burley, S. K., Hoch, J. C., Kurisu, G., Morris, K., Patwardhan, A., Velankar, S., Schwede, T., Trewhella, J., Kesselman, C., Berman, H. M., Sali, A.
    J. Mol. Biol 436, 168546 (2024)
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  5. PARP1-DNA co-condensation drives DNA repair site assembly to prevent disjunction of broken DNA ends
    Chappidi, N., Quail, T., Doll, S., Vogel, L. T., Aleksandrov, R., Felekyan, S., Kühnemuth, R., Stoynov, S., Seidel, C. A. M., Brugués, J., Jahnel, M., Franzmann, T. M., Alberti, S.
    Cell 187, 945-961 (2024)
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  6. Recognition of polymorphic Csd proteins determines sex in the honeybee.
    Otte, M., Netschitailo, O., Weidtkamp-Peters, S., Seidel, C. A. M., Beye, M.
    Sci. Adv. 9, eadg4239 (2023)
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  7. Luminescent Copper(I)-Complexes with an Anionic NHC: A Coordination Polymer as Versatile Precursor.
    Schmeinck, P., Sretenović, D., Guhl, J., Kühnemuth, R., Seidel, C. A. M., Marian, C. M., Suta, M., Ganter, C.
    ChemRxiv (2023)
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  8. Integrative dynamic structural biology unveils conformers essential for the oligomerization of a large GTPase.
    Peulen, T.-O., Hengstenberg, C. S., Biehl, R., Dimura, M., Lorenz, C., Valeri, A., Folz, J., Hanke, C. A., Ince, S., Vöpel, T., Faragó, B., Gohlke, H., Klare, J. P., Stadler, A. Seidel, C. A. M. , Herrmann, C.
    eLife 12, e79565 (2023)
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  9. Resolution of Maximum Entropy Method-derived posterior conformational ensembles of a flexible system probed by FRET and molecular dynamics simulations.
    Dittrich, J., Popara, M., Kubiak, J., Dimura, M., Schepers, B., Verma, N., Schmitz, B., Dollinger, P., Kovacic, F., Jaeger, K. E., Seidel, C. A. M., Peulen, T.-O., Gohlke, H.
    J. Chem. Theory Comput. 19, 2389–2409 (2023)
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  10. Reliability and accuracy of single-molecule FRET studies for characterization of structural dynamics and distances in proteins.
    Agam, G., Gebhardt, C., Popara, M., Mächtel, R., Folz, J., Ambrose, B., Chamachi, N., Chung, S. Y., Craggs, T. D., de Boer, M., Grohmann, D., Ha, T., Hartmann, A., Hendrix, J., Hirschfeld, V., Hübner, C. G., Hugel, T., Kammerer, D., Kang, H.-S., Kapanidis, A. N., Krainer, G., Kramm, K., Lemke, E., Lerner, E., Margeat, E., Martens, K., Michaelis, J., Mitra, J., Muñoz, G. G. M., Quast, R., Robb, N. B,, Sattler, M., Schlierf, M., Schneider, J., Schröder, T., Sefer, A., Tan, P. S., Thurn, J., Tinnefeld, P., van Noort, J., Weiss, S., Wendler, N., Zijlstra, N., Barth, A., Seidel, C. A. M., Lamb, D. C., Cordes, T.
    Nat. Methods 20, 523–535 (2023)
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  11. Increasing the Fluorescence Quantum Yield and Lifetime of the Flavin Chromophore by Rational Design.
    Kubitz, M. K., Haselbach, W., Sretenović, D., Bracker, M., Kleinschmidt, M., Kühnemuth, R., Seidel, C. A. M., Gilch, P., Czekelius, C.
    ChemPhotoChem 7, e202200334 (2023)
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  12. Enhanced solid-state fluorescence of flavin derivatives by in-corporation in the metal-organic frameworks MIL-53(Al) and MOF-5.
    Püschel, D., Hédé, S., Maisuls, I., Höfert, S.-P., Woschko, D., Kühnemuth, R., Felekyan, S., Seidel, C. A. M., Czekelius, C., Weingart, O., Strassert, C. A., Janiak, C.
    Molecules 28, e2877 (2023)
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  13. A minimal model of CD95 signal initiation revealed by advanced super-resolution and multiparametric fluorescence microscopy.
    Bartels, N., van der Voort, N. T. M., Greife, A., Bister, A., Wiek, C., Seidel, C. A. M., Monzel, C.
    bioRxiv (2022)
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  14. Fuzzy supertertiary interactions within PSD-95 enable ligand binding
    Hamilton, G. L., Saikia, N., Basak, S., Welcome, F. S., Wu, F., Kubiak, J., Zhang, C., Hao, Y., Seidel, C. A. M., Ding, F., Sanabria, H., Bowen, M. E.
    eLife 11, e77242 (2022)
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  15. A blind benchmark of kinetic analysis tools to infer kinetic rate constants from single-molecule FRET trajectories.
    Götz, M., Barth, A., Bohr, S. S.-R., Börner, R., Chen, J., Cordes, T., Erie, D. A., Gebhardt, C., Hadzic, M. C. A. S., Hamilton, G. L., Hatzakis, N. S., Hugel, T., Kisley, L., Lamb, D. C., de Lannoy, C., Mahn, C., Dunukara, D., de Ridder, D., Sanabria, H., Schimpf, J., Seidel, C. A. M., Sigel, R. K. O., Sletfjerding, M. B., Thomsen, J., Vollmar, L., Wanninger, S., Weninger, K. R., Xu, P., Schmid, S.
    Nat. Commun. 13, 5402 (2022)
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  16. Unraveling multi-state molecular dynamics in single-molecule FRET experiments. II. Quantitative analysis of multi-state kinetic networks.
    Opanasyuk, O., Barth, A., Peulen, T.-O., Felekyan, S., Kalinin, S., Sanabria, H., Seidel, C. A. M.
    J. Chem. Phys. 157, e031501 (2022)
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  17. Phase-separating RNA-binding proteins form heterogeneous distributions of clusters in subsaturated solutions.
    Kar. M., Dar, F., Welsh, T. J., Vogel, L. T., Kühnemuth, R., Majumdar, A., Krainer, G., Franzmann, T. M., Alberti, S., Seidel, C. A. M., Knowles T. P. J., Hyman A. A., Pappu, R. V.
    Proc. Natl. Acad. Sci. USA. 119, e2202222119 (2022)
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  18. Unraveling multi-state molecular dynamics in single-molecule FRET experiments. I. Theory of FRET-lines.
    Barth, A., Opanasyuk, O., Peulen, T.-O., Felekyan, S., Kalinin, S., Sanabria, H., Seidel, C. A. M.
    J. Chem. Phys. 156, e141501 (2022)
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  19. FRET nanoscopy enables seamless imaging of molecular assemblies with sub-nanometer resolution.
    Budde, J.-H., van der Voort, N.T.M., Felekyan, S., Folz, J., Kühnemuth, R., Lauterjung, P., Köhler, M., Schönle, A., Sindram, J., Otten, M., Karg, M., Herrmann, C., Barth, A. , Seidel, C. A. M.
    arXiv (2021)
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  20. Fundamental photophysics of isomorphic and expanded fluorescent nucleoside analogues.
    Dziuba, D., Didier, P., Ciaco, S., Barth, A., Seidel, C. A. M. , Mély, Y.
    Chem. Soc. Rev. 50, 7062-7107 (2021)
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  21. A comprehensive analysis of RAS-effector interactions reveals interaction hotspots and new binding partners.
    Rezaei Adariani, S., Kazemein Jasemi, N. S., Bazgir, F., Wittich, C., Amin, E., Seidel, C. A. M., Dvorsky, R. Ahmadian, M. R.
    J. Biol. Chem. 50, e100626 (2021)
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  22. FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices.
    Lerner, E., Barth, A., Hendrix, J., Ambrose, B., Birkedal, V., Blanchard, S. C., Börner, R., Chung. H. S., Cordes, T., Craggs, T. D., Deniz, A. A., Diao J., Fei J., Gonzalez, R. L., Gopich, I. V., Ha, T., Hanke, C. A., Haran, G., Hatzakis, N. S., Hohng S., Hong, S.-C., Hugel, T., Ingargiola, A., Joo, C., Kapanidis, A. N., Kim, H. D., Laurence, T., Lee, N. K., Lee, T.-H., Lemke E.-A., Margeat, E., Michaelis, J., Michalet, X., Myong, S., Nettels, D., Peulen, T.-O., Ploetz, E., Razvag, Y., Robb, N. C., Schuler, B., Soleimaninejad, H., Tang, C., Vafabakhsh, R., Lamb, D. C., Seidel, C. A. M., Weiss, S.
    eLife 10, e60416 (2021)
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  23. Automated and optimally FRET-assisted structural modeling.
    Dimura, M., Peulen, T.-O., Sanabria, H., Rodnin, D., Hemmen, K., Hanke, C.A., Seidel, C. A. M. , Gohlke, H.
    Nat. Commun. 11, e5394 (2020)
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  24. Resolving dynamics and function of transient states in single enzyme molecules.
    Sanabria, H., Rodnin, D., Hemmen, K., Peulen, T.-O., Felekyan, S., Fleissner, M. R., Dimura, M., Koberling, F., Kühnemuth, R., Hubbell, W., Gohlke, H., Seidel, C. A. M.
    Nat. Commun. 11, e1231 (2020)
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  25. Structural and dynamic insights revealing how lipase binding domain MD1 of Pseudomonas aeruginosa foldase affects lipase activation
    Viegas, A., Dollinger, P., Verma, N., Kubiak, J., Viennet, T., Seidel, C. A. M., Holger Gohlke, H., Etzkorn, M., Kovacic, F., Jaeger, K.-E.
    Sci. Rep. 10, e3578 (2020)
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  26. Specific conformational dynamics and expansion underpin a multi-step mechanism for specific binding of p27 with Cdk2/Cyclin A
    Tsytlonok, M., Hemmen, K., Hamilton, G., Kolimi, N., Felekyan, S., Seidel, C. A. M., Tompa, P., Sanabria, H.
    J. Mol. Biol. 432, 2998-3017 (2020)
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  27. Dynamics of the nucleosomal histone H3 N-terminal tail revealed by high precision single-molecule FRET
    Lehmann, K., Felekyan, S., Kühnemuth, R., Dimura, M., Tóth, K., Seidel, C. A. M., Langowski, J.
    Nucleic Acids Res., Volume 48, Issue 3, 1551-71 (2020)
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  28. Federating Structural Models and Data: Outcomes from A Workshop on Archiving Integrative Structures
    Berman, H.M., Adams, P.D., Bonvin, A.A., Burley, S.K., Carragher, B., Chiu, W., DiMaio, F., Ferrin, T.E., Gabanyi, M.J., Goddard, T.D., Griffin, P.R., Haas, J., Hanke, C.A., Hoch, J.C., Hummer, G., Kurisu, G., Lawson, C.L., Leitner, A., Markley, J.L., Meiler, J., Montelione, G.T., Phillips, G.N., Prisner, T., Rappsilber, J., Schriemer, D.C., Schwede, T., Seidel, C. A. M., Strutzenberg, T.S., Svergun, D.I., Tajkhorshid, E., Trewhella, J., Vallat, B., Velankar, S., Vuister, G.W., Webb, B., Westbrook, J.D., White, K.L., Sali, A.
    Structure 27, 1745-1759 (2019)
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  29. Dynamic anticipation by Cdk2/Cyclin A-bound p27 mediates signal integration in cell cycle regulation
    Tsytlonok, M., Sanabria, H., Wang, Y., Felekyan, S., Hemmen, K., Phillips, A.H., Yun, M.-K., Waddell, B., Park, C.-G., Vaithiyalingam, S., Iconaru, L., White, S.W., Tompa, P., Seidel, C. A. M., Kriwacki, R.
    Nat. Commun. 10, e1676 (2019)
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  30. Integrated NMR, fluorescence and MD benchmark study of protein mechanics and hydrodynamics
    Möckel, C., Kubiak, J., Schillinger, O., Kühnemuth, R., Della Corte, D., Schröder, G. F., Willbold, D., Strodel, B., Seidel, C. A. M., Neudecker, P.
    J. Phys. Chem. B 2019, 123, 1453-1480
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  31. High precision FRET studies reveal reversible transitions in nucleosomes between microseconds and minute
    Gansen, A., Felekyan, S., Kühnemuth, R., Lehmann, K., Tóth, K., Seidel, C. A. M., Langowski, J.
    Nat. Commun. 9, e4628 (2018)
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  32. Precision and accuracy of single-molecule FRET measurements – a multi-laboratory benchmark study
    Hellenkamp, B., Schmid, S., Doroshenko, O., Opanasyuk, O., Kühnemuth, R., Adariani, S. R., Ambrose, B., Aznauryan, M., Barth, A., Birkedal, V., Bowen, M. E., Chen, H., Cordes, T., Eilert, T., Fijen, C., Gebhardt, C., Götz, M., Gouridis, G., Gratton, E., Ha, T., Hao, P., Hanke, C. A., Hartmann, A., Hendrix, J., Hildebrandt, L. L., Hirschfeld, V., Hohlbein, J., Hua, B., Hübner, C. G., Kallis, E., Kapanidis, A. N., Kim, J.-Y., Krainer, G., Lamb, D. C., Lee, N. K., Lemke, E. A., Levesque, B., Levitus, M., McCann, J. J., Naredi-Rainer, N., Nettels, D., Ngo, T., Qiu, R., Robb, N. C., Röcker, C., Sanabria, H., Schlierf, M., Schröder, T., Schuler, B., Seidel, H., Streit, L., Thurn, J., Tinnefeld, P., Tyagi, S., Vandenberk, N., Vera, A. M., Weninger, K. R., Wünsch, B., Yanez-Orozc, I. S., Michaelis, J., Seidel, C. A. M., Craggs, T. D., Hugel, T.
    Nat. Methods 15, 669–676 (2018)
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  33. Single-molecule FRET reveals multiscale chromatin dynamics modulated by HP1α
    Kilic, S., Felekyan, S., Doroshenko, O., Boichenko, I., Dimura, M., Vardanyan, H., Bryan, L. C., Arya, G., Seidel, C. A. M., Fierz, B.
    Nat. Commun. 9, e235 (2018)
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  34. Combining graphical and analytical Methods with molecular simulations to analyze time-resolved FRET-measurements of labeled macromolecules accurately
    Peulen, T.-O., Opanasyuk, O., Seidel, C. A. M.
    J. Phys. Chem. B. 121, 8211-8241 (2017)
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  35. Uptake dynamics of graphene quantum dots into primary human blood cells following in vitro exposure
    Fasbender, S., Allani, S., Wimmenauer, C., Cadeddu, R.-P., Raba, K., Fischer, J. C., Bulat, B., Luysberg, M., Seidel, C. A. M., Heinzel, T., Haas, R.
    RSC Adv. 7, 12208-12216 (2017)
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  36. Quantitative FRET studies and integrative modeling unravel the structure and dynamics of biomolecular systems
    Dimura, M., Peulen, T.-O., Hanke, C. A., Prakash, A., Gohlke, H., Seidel, C. A. M.
    Curr. Opin. Struct. Biol. 40, 163-185 (2016)
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  37. Structural assemblies of the di- and oligomeric G-protein coupled receptor TGR5 in live cells: an MFIS-FRET and integrative modelling study
    Greife, A., Felekyan, S., Ma, Q., Gertzen, C. G. W., Spomer, L., Dimura, M., Peulen, T.-O., Wöhler, C., Häussinger, D., Gohlke, H., Keitel, V., Seidel, C. A. M.
    Sci. Rep. 6, 36792 (2016)
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  38. Diffusion of macromolecules in a polymer hydrogel: from microscopic to macroscopic scales
    Sandrin, D., Wagner, D., Sitta, C. E., Thoma, R., Felekyan, S., Hermes, H. E., Janiak, C., de Sousa Amadeu, N., Kühnemuth, R., Löwen, H., Egelhaaf, S. U., Seidel, C. A. M.
    Phys. Chem. Chem. Phys. 18, 12860-12876 (2016)
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  39. Guanylate binding proteins (GBPs) directly attack T. gondii via supramolecular complexes
    Kravets, E., Degrandi, D., Ma, Q., Peulen, T.-O., Klümpers, V., Felekyan, S., Kühnemuth, R., Weidtkamp-Peters, S., Seidel, C. A. M., Pfeffer, K.
    eLife 2016; 5:e.11479 (2016)
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  40. Structures of adsorption layers of surfactant mixtures on nonpolar solid surfaces
    von Rybinski, W., Jabnoun, M., van Megen, J., Oesterhelt, F., Seidel, C. A. M.
    Colloid Polym Sci 396, 3107–3117 (2015)
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  41. Real-time dynamics of peptide ligand–dependent receptor complex formation in planta
    Somssich, M., Ma, Q., Weidtkamp-Peters, S., Stahl, Y., Felekyan, S., Bleckmann, A., Seidel, C. A. M., Simon, R.
    Sci. Signal 8, ra76 (2015)
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  42. Outcome of the First wwPDB Hybrid/Integrative Methods Task Force Workshop
    Sali, A., Berman, H. M., Schwede, T., Trewhella, J., Kleywegt, G., Burley, S. K., Markley, J., Nakamura, H., Adams, P., Bonvin, A. M. J. J., Chiu, W., Dal Peraro, M., Di Maio, F., Ferrin, T. E., Grünewald, K., Gutmanas, A., Henderson, R., Hummer, G., Iwasaki, K., Johnson, G., Lawson, C. L., Meiler, J., Marti-Renom, M. A., Montelione, G. T., Nilges, M., Nussinov, R., Patwardhan, A., Rappsilber, J., Read, R. J., Saibil, H., Schröder, G. F., Schwieters, C. D., Seidel, C. A. M., Svergun, D., Topf, M., Ulrich, E. L., Velankar, S., Westbrook, J. D.
    Structure 23, 1156-1167 (2015)
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  43. Temperature-cycle microscopy reveals single-molecule conformational heterogeneity
    Yaun, H., Gaiduk, A., Siekierzycka, J. R., Fujiyoshi, S., Mustushita, M., Nettels, D., Schuler, B., Seidel, C. A. M., Orrit, M.
    Phys. Chem. Chem. Phys. 17, 6532-6544 (2015)
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  44. Fine tuning of sub-millisecond conformational dynamics controls metabotropic glutamate receptors agonist efficacy
    Olofsson, L., Felekyan, S., Doumazane, E., Scholler, P., Fabre, L., Zwier, J. M., Rondard, P., Seidel, C. A. M., Pin, J. P., Margeat, E.
    Nat. Commun.5, 5206 (2014)
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  45. Triphosphate induced dimerization of human guanylate binding protein 1 involves association of the C-Terminal helices: a joint DEER and FRET study
    Vöpel, T., Hengstenberg, C. S., Peulen, T.-O., Ajaj, Y., Seidel, C. A. M., Herrmann, C., Klare, J. P.
    Biochemistry 53, 4590-4600 (2014)
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  46. Molecules under pressure
    Seidel, C. A. M., Kühnemuth, R.
    Nat. Nanotech. 9, 164-165 (2014)
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  47. dNTP-dependent conformational transitions in the fingers subdomain of Klentaq1 DNA polymerase: insights into the role of the “nucleotide binding” state
    Rothwell, P. J., Allen, W. J., Sisamakis, E., Kalinin, S., Felekyan, S., Widengren, J., Waksman, G., Seidel, C. A. M.
    J. Biol. Chem. 288, 13575–13591 (2013)
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  48. Impact of human autoantibodies on ß1-adrenergic receptor conformation, activity, and internalization
    Bornholz, B., Weidtkamp-Peters, S., Schmitmeier, S., Seidel, C. A. M., Herda, L. R., Felix, S. B., Lemoine, H., Hescheler, J., Nguemo, F., Schäfer, C., Christensen, M. O., Mielke, C., Boege, F.
    Cardiovascular Research 97, 472-480 (2013)
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  49. Moderation of Arabidopsis root stemness by CLAVATA1 and ARABIDOPSIS CRINKLY4 receptor kinase complexes
    Stahl, Y., Grabowski, S., Bleckmann, A., Kühnemuth, R., Weidtkamp-Peters, S., Pinto, K. G., Kirschner, G. K., Schmid, J. B., Wink, R. H., Hülsewede, A., Felekyan, S., Seidel, C. A. M., Simon, R.
    Curr. Biol. 23, 362–371 (2013)
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  50. Analyzing Förster resonance energy transfer with fluctuation algorithms
    Felekyan, S., Sanabria, H., Kalinin, S., Kühnemuth, R., Seidel, C. A. M.
    Methods in Enzymology 519, (Fluorescence Fluctuation Spectroscopy (FFS) Part B, Ed. Sergey Y. Tetin, UK, Academic Press, ISBN: 978-0-12-405539-1) Chapter 2, 39-86 (2013)
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  51. A toolkit and benchmark study for FRET-restrained high-precision structural modeling
    Kalinin, S., Peulen, Th.-O., Sindbert, S., Rothwell, P. J., Berger, S., Restle, T., Goody, R. S., Gohlke, H., and Seidel, C. A. M.
    Nat. Methods 9, 1218-1225 (2012)
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  52. A 4 ns hardware photon correlator based on a general-purpose FPGA development board implemented in a compact setup for fluorescence correlation spectroscopy
    Kalinin, S., Kühnemuth, R., Vardanyan, H., Seidel, C. A. M.
    Rev. Sci. Instrum. 83, 096105 (2012)
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  53. The supertertiary structure of the synaptic MAGuK scaffold proteins is conserved
    McCann, J. J., Zheng, L. Rohrbeck, D., Felekyan, S., Kühnemuth, R., Sutton, R. B., Seidel, C. A. M., Bowen, M. E.
    Proc. Natl. Acad. Sci. USA. 109, 15775-15780 (2012)
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  54. The GTPase activity of murine guanylate-binding protein 2 (mGBP2) controls the intracellular localization and recruitment to the parasitophorous vacuole of Toxoplasma gondii
    Kravets, E., Degrandi, D., Weidtkamp-Peters, S., Felekyan, S., Tschapek, B., Konermann, C., Fres, J., Praefcke, G., Seidel, C. A. M., Schmitt, L., Smits, S.H.J., Pfeffer, K.
    J. Biol. Chem. 287, 27452–27466 (2012)
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  55. Single-molecule multiparameter fluorescence spectroscopy reveals directional MutS binding to mismatched bases in DNA
    Cristóvão, M., Sisamakis, E., Hingorani, M. M., Marx, A. D., Jung, C. P., Rothwell, P. J., Seidel, C. A. M., Friedhoff, P.
    Nucl. Acids Res. 40, 5448-5464 (2012)
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  56. Filtered FCS: Species auto and cross correlation functions highlight binding and dynamics in biomolecules
    Felekyan, S., Kalinin, S., Sanabria, H., Valeri, A., Seidel, C. A. M.
    ChemPhysChem 13, 1036-1053 (2012)
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  57. Combining MFD and PIE for accurate single-pair Förster Resonance Energy Transfer measurements
    Kudryavtsev, V., Sikor, M., Kalinin, S., Mokranjac, D., Seidel, C. A. M., Lamb, D. C.
    ChemPhysChem 13, 1060-1078 (2012)
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  58. High-precison FRET zum quantitativen Studium der Struktur und Dynamik von Biomolekülen
    Peulen, Th.-O., Seidel, C. A. M.
    Biospektrum 17, 765-767 (2011)
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  59. Structural heterogeneity and quantitative FRET efficiency distributions of polyprolines through a hybrid atomistic simulation and Monte Carlo approach
    Hoefling, M., Lima, N., Haenni, D., Seidel, C. A. M., Schuler, B., Grubmüller, H.
    PLoS ONE 6(5), e19791 (2011)
    Full text | Requests
     

  60. Accurate distance determination of nucleic acids via FRET: Implications of dye linker length and rigidity
    Sindbert, S., Kalinin, S., Nguyen, H., Kienzler, A., Clima, L., Bannwarth, W., Appel, B., Müller, S., Seidel, C. A. M.
    J. Am. Chem. Soc. 133, 2463-2480 (2011)
    Full text | Requests

     

  61. Detection of structural dynamics by FRET: A photon distribution and fluorescence lifetime analysis of systems with multiple states
    Kalinin, S., Valeri A., Antonik M., Felekyan, S., Seidel, C. A. M.
    J. Phys. Chem. B. 114, 7983–7995 (2010)
    Full text | Requests
     

  62. Accurate single-molecule FRET studies using multiparameter fluorescence detection
    Sisamakis, E., Valeri, A., Kalinin, S., Rothwell, P. J., Seidel, C. A. M.
    Methods in Enzymology 475 (Single Molecule Methods, Part B: Multiparameter, super-resolution, tethering, and force based methods, Ed. Nils Walter) Chapter 18, 455-514 (2010)
    Full text | Requests
     

  63. On the origin of broadening of single-molecule FRET efficiency distributions beyond shot noise limits
    Kalinin, S., Sisamakis, E., Magennis, S.W., Felekyan, S., Seidel, C. A. M.
    J. Phys. Chem. B. 114, 6197–6206 (2010)
    Full text | Requests
     

  64. The conformational dynamics of the mitochondrial Hsp70 chaperone
    Mapa, K., Sikor, M., Kudryavtsev, V., Waegemann, K., Kalinin, S., Seidel, C. A. M., Neupert, W., Lamb, D. C., Mokranjac, D.
    Mol. Cell 38, 89–100 (2010)
    Full text | Requests
     

  65. Diphenylhexatrienes as photoprotective agents for ultrasensitive fluorescence detection
    Pfiffi, D., Bier, B.A., Marian, C.M., Schaper, K., Seidel, C. A. M.
    J. Phys. Chem. A. 114, 4099–4108 (2010)
    Full text | Requests
     

  66. Stem cell signalling in Arabidopsis requires CRN to localize CLV2 to the plasma membrane
    Bleckmann, A., Weidtkamp-Peters, S., Seidel, C. A. M., Simon, R.,
    Plant Physiol. 152, 166-76 (2010)
    Full text | Requests
     

  67. Nucleosome disassembly intermediates characterized by single-molecule FRET
    Gansen, A., Valeri, A., Hauger, F., Felekyan, S., Kalinin, S., Tóth, K., Langowski, J., Seidel, C. A. M.
    Proc. Natl. Acad. Sci. USA. 106, 15308-15313 (2009)
    Full text | Requests
     

  68. Fluorophores as optical sensors for local forces
    Marawske, S., Dörr, D., Schmitz, D., Koslowski, A., Lu, Y., Ritter, H., Thiel, W., Seidel, C. A. M., Kühnemuth, R.
    Chem. Phys. Chem, 10, 2041-2048 (2009)
    Full text | Requests
     

  69. Multiparameter Fluorescence Image Spectroscopy to study molecular interactions
    Weidtkamp-Peters, S., Felekyan, S., Bleckmann, A., Simon, R., Becker, W., Kühnemuth, R., Seidel, C. A. M.
    Photochem. Photobiol. Sci., 8, 470-480 (2009)
    Full text | Requests
     

  70. Filtered FCS and Species Cross Correlation Function
    Felekyan, S., Kalinin, S., Valeri, A., Seidel, C. A. M.
    Proc. SPIE 7183, (Multiphoton Microscopy in the Biomedical Sciences IX), 71830D (2009)
    Full text | Requests
     

  71. Structural Changes of Yellow Cameleon Domains Observed by Quantitative FRET Analysis and Polarized Fluorescence Correlation Spectroscopy
    Borst, J.W., Laptenok, S.P., Westphal, A.H., Kühnemuth, R., Hornen, H., Visser, N.V., Kalinin, S., Aker, J., van Hoek, A., Seidel, C. A. M., Visser, A.J.W.G.
    Biophys. J., 95, 5399-411 (2008)
    Full text | Requests
     

  72. Dynamics of supramolecular association monitored by fluorescence correlation spectroscopy
    Al-Soufi, W., Reija, B., Felekyan, S., Seidel, C. A. M., Novo, M.
    ChemPhysChem 9, 1819-1827 (2008)
    Full text | Requests
     

  73. Single-molecule FRET measures bends and kinks in DNA
    Woźniak, A. K., Schröder, G. F., Grubmüller, H., Seidel, C. A. M., Oesterhelt F.
    Proc. Natl. Acad. Sci. USA. 105, 18337-42 (2008)
    Full text | Requests
     

  74. Characterizing multiple molecular states in single-molecule multi-parameter fluorescence detection by probability distribution analysis.
    Kalinin, S., Felekyan, S., Valeri, A., Seidel, C. A. M.
    J. Phys. Chem. B 112, 8361-8374 (2008)
    Full text | Requests
     

  75. Probability Distribution Analysis of Single-Molecule Fluorescence Anisotropy and Resonance Energy Transfer
    Kalinin, S., Felekyan, S. Antonik, M., Seidel, C. A. M.
    J. Phys. Chem. B 111, 10253-10262 (2007)
    Full text | Requests
     

  76. Orientational and dynamical heterogeneity of Rhodamine 6G terminally attached to a DNA helix revealed by NMR and single-molecule fluorescence spectroscopy.
    Neubauer, H., Gaiko, N., Berger, S., Schaffer, J., Eggeling, C., Verdier, L. Seidel, C. A. M., Griesinger C., Volkmer, A.
    J. Am. Chem. Soc. 129, 12746-12755 (2007)
    Full text | Requests
     

  77. Fluorescence detection with high time-resolution: From optical microscopy to simultaneous force and fluorescence spectroscopy
    Gaiduk, A., Kühnemuth, R., Felekyan, S., Antonik, M., Becker, W., Kudryavtsev, V., Sandhagen, C. Seidel, C. A. M.
    Microscopy Research and Technique, 70, 433-441 (2007)
    Full text | Requests
     

  78. Dye-Exchange Dynamics in Micellar Solutions studied by Fluorescence Correlation Spectroscopy
    Novo, M., Felekyan S., Seidel, C. A. M., Al Soufi, W.
    J. Phys. Chem. B 111, 3614-3624 (2007)
    Full text | Requests
     

  79. Strategies to improve photostabilities in ultrasensitive fluorescence spectroscopy
    Widengren, J., Chmyrov, A., Eggeling, C., Löfdahl, P.-Å., Seidel, C. A. M.
    J. Phys. Chem. A 111, 429-440 (2007)
    Full text | Requests
     

  80. Multiparameter fluorescence imaging to monitor dynamic systems
    Kudryavtsev, V., Felekyan, S., Woźniak, A. K., König, M., Sandhagen, C., Kühnemuth, R., Seidel, C. A. M., Oesterhelt, F.
    Anal. Bioanal. Chem. 387, 71-82 (2007)
    Full text | Requests
     

  81. Time-resolved photon counting allows for new temporal and spatial insights into the nanoworld
    Gaiduk, A., Kühnemuth, R., Felekyan, S., Antonik, M., Becker, W., Kudryavtsev, V., König, M., Oesterhelt, F., Sandhagen, C. Seidel, C. A. M.
    Proc. of SPIE- Int. Soc. Opt. Eng 6372 (Advanced Photon Counting Techniques, edited by Wolfgang Becker), 637203 (2006)
    Full text | Requests
     

  82. Separating structural heterogeneities from stochastic variations in fluorescence resonance energy transfer distributions via photon distribution analysis
    Antonik, M., Felekyan, S., Gaiduk, A., Seidel, C. A. M.
    J. Phys. Chem. B 110, 6970-6978 (2006)
    Full text | Requests
     

  83. Analysis of photobleaching in single-molecule multicolour excitation and fluorescence resonance energy transfer measurements
    Eggeling, C., Widengren, J., Brand, L., Schaffer, J., Felekyan, S., Seidel, C. A. M.
    J. Phys. Chem. A 110, 2979-2995 (2006)
    Full text | Requests
     

  84. Single molecule detection and identification of multiple species by multiparameter fluorescence detection
    Widengren, J., Kudryavtsev, V., Antonik, M., Berger, S., Gerken, M., Seidel, C. A. M.
    Anal. Chem. 78, 2039-2050 (2006)
    Full text | Requests

     

  85. Detecting protein-induced folding of the U4 snRNA kink-turn by single-molecule multiparameter FRET measurements
    Woźniak, A. K., Nottrott, S., Kühn-Hölsken, E., Schröder, G. F., Grubmüller, H., Lührmann, R., Seidel, C. A. M., Oesterhelt F.
    RNA, 11, 1545-1554 (2005)
    Full text | Requests
     

  86. Full correlation from picoseconds to seconds by time-resolved and time-correlated single photon detection
    Felekyan, S., Kühnemuth, R., Kudryavtsev, V., Sandhagen, C., Becker, W., Seidel, C. A. M.
    Rev. Sci. Instr. 76, 083104 (2005)
    Full text | Requests
     

  87. Fluorescence correlation spectroscopy, a tool to investigate supramolecular dynamics: Inclusion complexes of pyronines with cyclodextrines
    Al-Soufi, W., Reija, B., Novo M., Felekyan, S., Kühnemuth, R., Seidel, C. A. M.,
    J. Am. Chem. Soc. 127, 8775-8784 (2005)
    Full text | Requests
     

  88. Optical characteristics of AFM tips for single molecule fluorescence applications
    Gaiduk, A., Kühnemuth, R., Antonik, M., Seidel, C. A. M.
    ChemPhysChem 6, 976-983 (2005)
    Full text | Requests
     

  89. Molecular photobleaching kinetics of Rhodamine 6G under the conditions of one- and two-photon induced confocal fluorescence microscopy
    Eggeling, C., Volkmer, A., Seidel, C. A. M.
    ChemPhysChem 6, 791-804 (2005)
    Full text | Requests
     

  90. Fluorescence labeling of RNA for single molecule studies,
    Oesterhelt, F., Schweinberger, E., Seidel, C. A. M.
    Handbook of RNA Biochemistry, Eds. Hartmann R. K., Bindereif A., Schön A., Westhof E., Wiley-VCH, Weinheim, 453-474 (2005)
    Full text | Requests
     

  91. Determinants of liposome fusion mediated by synaptic SNARE proteins
    Schuette, C.G., Hatsuzawa, K., Margittai, M., Stein, A., Riedel, D., Küster, P., König, M., Seidel, C. A. M., Jahn, R.
    Proc. Natl. Acad. Sci. USA. 101, 2858-2863 (2004)
    Full text | Requests
     

  92. Proton-powered subunit rotation in single membrane-bound F0F1-ATP synthase
    Diez, M., Zimmermann, B., Börsch, M., König, M., Schweinberger, E., Steigmiller, S., Reuter, R., Felekyan, S., Kudryavtsev, V. Seidel, C. A. M., Gräber, P.
    Nat. Struct. Mol. Biol. 11, 135-141 (2004)
    Full text | Requests
     

  93. Single molecule FRET dynamics reveals an equilibrium between a closed and an open conformation of syntaxin
    Margittai, M., Schweinberger, E., Widengren, J., Fasshauer, D., Schroder, G., Haustein, E., Felekyan, S., König, M., Grubmüller, H., Jahn, R., Seidel, C. A. M.
    Proc. Natl. Acad. Sci. USA. 100, 15516-15521 (2003)
    Full text | Requests
     

  94. Multi-parameter Single-molecule Fluorescence Spectroscopy reveals Heterogeneity of HIV-1 Reverse Transcriptase:primer/template Complexes
    Rothwell, P., Berger, S., Kensch, O., Felekyan, S., Antonik, M., Restle, T., Wöhrl, B., Goody, R., Seidel, C. A. M.
    Proc. Natl. Acad. Sci. USA. 100, 1655-1660 (2003)
    Full text | Requests
     

  95. Principles of single molecule multiparameter fluorescence spectroscopy
    Kühnemuth, R., Seidel, C. A. M.
    Single Molecules 2, 251-254 (2001)
    Full text | Requests
     

  96. Two new concepts to measure fluorescence resonance energy transfer via fluorescence correlation spectroscopy: Theory and experimental realizations
    Widengren, J., Schweinberger, E., Berger, S., C., Seidel, C. A. M.
    J. Phys. Chem. A 105, 6851-6866 (2001)
    Full text | Requests
     

  97. Fluoreszenzspektroskopie an einzelnen Molekülen
    Seidel, C. A. M., Kühnemuth, R.
    Nachr. aus der Chemie 49, 346-350 (2001)
    Full text | Requests
     

  98. Homogeneity, transport and signal properties of single Ag-particles studied by single-molecule surface enhanced resonance Raman scattering
    Eggeling, C., Schaffer, J., Seidel, C. A. M., Korte, J., Brehm, G., Schneider, S., Schrof, W.
    J. Phys. Chem. A. 105, 3673-3679 (2001)
    Full text | Requests
     

  99. An experimental comparison of the maximum likelihood estimation and nonlinear Least-Squares fluorescence lifetime analysis of single molecules
    Maus, M., Cotlet, M., Hofkens, J., Gensch, T., De Schryver, F. C., Schaffer, J., Seidel, C. A. M.
    Anal. Chem. 73, 2078-2086 (2001)
    Full text | Requests
     

  100. Data registration and selective single-molecule analysis using multi-parameter fluorescence detection
    Eggeling, C., Berger, S., Brand, L., Fries, J. R., Schaffer, J., Volkmer, A., Seidel, C. A. M.
    J. Biotechnol. 86, 163-180 (2001)
    Full text | Requests
     

  101. Manipulation and characterization of photo-induced states of merocyanine 540 by fluorescence correlation spectroscopy
    Widengren, J., Seidel, C. A. M.
    Phys.Chem.Chem.Phys. 2, 3435-3441 (2000)
    Full text | Requests
     

  102. Photochromicity and fluorescence lifetimes of green fluorescent protein
    Striker, G., Subramaniam,V., Seidel, C. A. M., Volkmer, A.
    J. Phys. Chem. B. 103, 8612-8617 (1999)
    Full text | Requests
     

  103. Identification of single molecules in aqueous solution by time-resolved fluorescence anisotropy
    Schaffer, J., Volkmer, A., Eggeling, C., Subramaniam,V., Striker, G., Seidel, C. A. M.
    J. Phys. Chem. A. 103, 331-336 (1999)
    Full text | Requests
     

  104. Change of diffusion coefficient of ECF1 upon nucleotide binding detected by single molecule fluorescence
    Börsch, M., Turina, P., Eggeling, C., Fries, J. R., Seidel, C. A. M., Labahn, A., Gräber, P.
    Italian Biochemical Society Transaction 11, 47-50 (1998)
    Requests
     

  105. Conformational Changes of the H+-ATPase from E.coli upon binding detected by single molecule fluorescence
    Börsch, M., Turina, P., Eggeling, C., Fries, J. R., Seidel, C. A. M., Labahn, A., Gräber, P.
    FEBS Lett. 437, 251-254 (1998)
    Full text | Requests
     

  106. Quantitative identification of different single molecules by selective time-resolved confocal fluorescence spectroscopy
    Fries, J. R., Brand, L., Eggeling, C., Köllner, M., Seidel, C. A. M.
    J. Phys. Chem. A. 102, 6601-6613 (1998). b) Described in "News" section in Anal. Chem. 70, 636A (1998)
    Full text | Requests
     

  107. Photostability of fluorescent dyes for single-molecule spectroscopy: Mechanisms and experimental methods for estimating photobleaching in aqueous solution
    Eggeling, C., Widengren, J., Rigler, R., Seidel, C. A. M.
    In: Applied Fluorescence in Chemistry, Biology and Medicine; Eds.: Rettig, W., Strehmel, B., Schrader, S., Seifert, H.; Springer-Verlag, Berlin, 193-240 (1999)
    Full text | Requests
     

  108. Photobleaching of fluorescent dyes under conditions used for single-molecule detection: Evidence of two-step photolysis
    Eggeling, C., Widengren, J., Rigler, R., Seidel, C. A. M.
    Anal. Chem. 70, 2651-2659 (1998)
    Full text | Requests
     

  109. Monitoring conformational dynamics of a single molecule by selective fluorescence spectroscopy
    Eggeling, C., Fries, J. R., Brand, L., Günther, R., Seidel, C. A. M.
    Proc. Natl. Acad. Sci. USA. 95, 1556-1561 (1998)
    Full text | Requests
     

  110. Laser-induced fluorescence detection of coumarin derivatives in aqueous solution: photochemical aspects for single molecule detection
    Eggeling, C., Brand, L., Seidel, C. A. M.
    Bioimaging 5, 105-115 (1997)
    Full text | Requests
     

  111. Single-molecule detection of Coumarin-120
    Seidel, C. A. M., Brand, L., Eggeling, C.,
    Nucleosides Nucleotides 16, 551-556 (1997)
    Full text | Requests
     

  112. Single-molecule detection by two-photon excitation of fluorescence
    Zander, C., Brand, L., Eggeling, C., Drexhage, K. H., Seidel, C. A. M.
    Proc. SPIE-Int. Soc. Opt. Eng. 2980 (Advances in fluorescence sensing technology III), 552-558 (1997)
    Full text | Requests
     

  113. Lifetime-identification of single molecules in aqueous solution
    Zander, C., Drexhage, K. H., Sauer, M., Brand, L., Eggeling, C., Seidel, C. A. M.
    Proc. SPIE-Int. Soc. Opt. Eng. 2980 (Advances in fluorescence sensing technology III), 107-114 (1997)
    Full text | Requests
     

  114. Single-molecule identification of Coumarin-120 by time-resolved fluorescence detection: Comparison of one- and two-photon excitation in solution
    Brand, L., Eggeling, C., Zander, C., Drexhage, K. H., Seidel, C. A. M.,
    J. Phys. Chem. A. 101, 4313-4321 (1997)
    Full text | Requests
     

  115. Solvent polarity dependent quenching of pyrene-butyric -acid
    Seidel, C. A. M., Brand, L., von Frese,C. M.
    J. Fluores. 7, 67S-69S (1997)
    Requests
     

  116. Detection and characterization of single molecules in aqueous solution
    Zander, C., Sauer, M., Drexhage, K. H., Ko, D.-S., Schulz, A., Wolfrum, J., Brand, L., Eggeling, C., Seidel, C. A. M.
    Appl. Phys. B, 63, 517-523 (1996)
    Full text | Requests
     

  117. Nucleobase specific quenching of fluorescent dyes. I. Nucleobase one-electron redox potentials and their correlation with static and dynamic quenching efficiencies
    Seidel, C. A. M., Schulz, A., Sauer, H. M.
    J. Phys. Chem. 100, 5541-5553 (1996)
    Full text | Requests
     

  118. Characterization of HIV-1 Rev by (time-resolved) fluorescence spectroscopy.
    Kungl, A. J., Seidel, C. A. M., Schilk, A., Daly, T.J., Kauffmann, H. F., Auer, M.
    J. Fluores. 4, 299-302 (1994)
    Full text | Requests
     

  119. Electronic effects on the fluorescence of tyrosine in small peptides.
    Seidel, C. A. M., Orth, A., Greulich, K.-O.
    Photochem. Photobiol. 58, 178-184 (1993)
    Full text | Requests
     

  120. Characterization of fluorescence-labeled DNA by time-resolved fluorescence spectroscopy
    Seidel, C. A. M., Rittinger, K., Cortés, J., Goody, R. S., Köllner, M., Wolfrum, J., Greulich, K. O.
    Proc. SPIE 1432, Biomolecular Spectroscopy II, (1991)
    Full text | Requests
     

  121. Nucleic Acid Base Specific Quenching of a Coumarin-120-Derivative in Nucleotid-Conjugates - Photoinduced Electron Transfer
    Seidel, C. A. M.
    Proc. SPIE 1432, Biomolecular Spectroscopy II, (1991)
    Full text | Requests
     

  122. Laser Femtosecond MPI Mass Spectrometry of Dye-Labelled Nucleotides
    Chekalin, S. V., Golovlev, V. V., Matveets, Yu. A., Yartsev, A. P., Letokhov, V. S., Seidel, C. A. M., Wolfrum, J., Greulich, K. O.
    IEEE J. Quantum Electron. 26, 2158-2161 (1990)
    Full text | Requests
     

  123. A DFDL picosecond Fluorescence Spectrometer: Application to aqueous Solutions of Peptides and Nucleotide Dye Conjugates
    Schwarzwald, R., Seidel, C. A. M., Goody, R. S., Kühn, K. P., Greulich, K. O.
    Ber. Bunsenges. Phys. Chem. 93, 342-346 (1989)
    Full text | Requests
     

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Prof. Dr. Claus A. M. Seidel
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